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The mission of Dr. Hancock's research program is the study of Glycoproteomics and glycans associated with cancer and infectious disease. Our studies involve the analysis of candidate biomarkers from both patient tissue and blood samples and we use panels of lectins (sugar binding proteins) to isolate and detect changes in glycan composition in disease. Current active areas include breast and renal cancer and study of the AIDS virus. The second area of research is the study of biotechnology protein drugs which is an area which requires that latest in mass spectrometry technology especially with the emergence of biogeneric drugs. We are currently analyzing growth hormone, interferon and antibody drugs and developing new analytical approaches for study variants caused by changes in disulfides, glycosylation as well as degradative reactions such as oxidation, deamidation and aggregation. |