Sung-Hou Kim
Department of Chemistry, University of California, USA
I. Structural biology of molecular signaling: Structural basis for understanding how molecules communicate to each other to activate or inhibit particular processes are probed by experimentally determining and understanding three-dimensional structures of molecules associated with several important signaling pathways, such as cell growth, cell differentiation, and cancer.
II. Structural Genomics and Proteomics: Architectural motifs of proteins used by all organisms are very similar. Computational methods have been developed to classify the motifs and to discover possible evolutionary relationships among the motifs.
III. Demography and phylogeny of whole genomes/proteomes: An explosive number of whole genome sequences have been determined in the current decade. Computational methods have been developed to group all known whole genome sequences based on their similarities. This approach provides global views of demography and phylogeny (relationship among the demographic groups) of whole genome sequences, thus, of organisms.
IV. Drug discovery: Co-founded a drug discovery company to explore practical application of scaffold-based approaches to drug discovery, especially protein kinase family as drug target.